Article
Whole-exome sequencing of alpha-fetoprotein producing gastric carcinoma reveals genomic profile and therapeutic targets.
Nature communications - 24 Jun 2021
Lu Jun, Ding Yongfeng, Chen Yanyan, Jiang Junjie, Chen Yiran, Huang Yingying, Wu Mengjie, Li Chengzhi, Kong Mei, Zhao Wenyi, Wang Haohao, Zhang Jing, Li Zhongqi, Lu Yimin, Yu Xiongfei, Jin Ketao, Zhou Donghui, Zhou Tianhua, Teng Fei, Zhang Haibin, Zhou Zhan, Wang Haiyong, Teng Lisong
Abstract excerpt
Alpha-fetoprotein producing gastric carcinoma (AFPGC) is a rare and aggressive subtype of gastric cancer. However, little is known about the genomic features of this disease. We perform whole-exome sequencing analysis of AFPGC, and identify 34 significantly mutated genes. Somatic copy number alterations analysis reveals several significant focal amplifications (e.g. 19q12, 17q12) and focal deletions (e.g....
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