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Article

Hepatoid adenocarcinoma of the stomach and non-hepatoid alpha-fetoprotein-producing gastric cancer exhibit a high degree of molecular similarity.

Cellular oncology (Dordrecht, Netherlands) - 22 Dec 2025

Chen Liqiao, Yang Xuesong, Zhu Peiyu, Bao Han, Wu Yan, Ji Ke, Zhang Ji, Wu Xiaojiang, Zhou Kai, Xu Jieli, Tang Jiatian, Wang Anqiang, Bu Zhaode

Abstract excerpt

BACKGROUND: There is currently no unified consensus on the diagnosis and treatment of hepatoid adenocarcinoma of the stomach (HAS) and non-hepatoid AFP-producing gastric cancer (AFPGC). This study aims to explore the molecular similarities between the two, providing a basis for the diagnosis and precision treatment of these patients. METHODS: We retrospectively collected tumor tissues, adjacent tissues, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41428143
DOI: 10.1007/s13402-025-01145-7
PMCID: PMC12722461

Genes

FAT4
AFP
CCNE1
CSMD3
ERBB2
LRP1B
MUC16
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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