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Article

Genomic landscape and potential therapeutic targets in alpha-fetoprotein-producing gastric cancer.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 May 2025

Zan Likun, Zhang Xin, Shen Lulu, Zhao Qi, Tan Dongfeng, Peng Xiao, Jia Yi, Li Jiawen, Liu Jing, Zhao Jiaqi, Gao Ning, Bu Peng, Xi Yanfeng

Abstract excerpt

Alpha-fetoprotein-producing gastric carcinoma (AFPGC) is a rare and aggressive subtype of gastric cancer (GC). A comprehensive analysis of clinicopathological features, immunophenotypes, molecular characteristics, and survival in AFPGC contributes to identifying potential therapeutic targets and developing new strategies to manage this disease. A retrospective cohort study was conducted at Shanxi Cancer Hospital...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39928247
DOI: 10.1007/s10120-025-01594-x
PMCID: PMC11993487

Genes

AFP
GC
ARID1A
CCNE1
EGFR
ERBB2
GPC3
LRP1B
SALL4
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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