Article
Gene Set Enrichment Analsyes Identify Pathways Involved in Genetic Risk for Diabetic Retinopathy.
American journal of ophthalmology - 1 Jan 2022
Sobrin Lucia, Susarla Gayatri, Stanwyck Lynn, Rouhana John M, Li Ashley, Pollack Samuela, Igo Robert P, Jensen Richard A, Li Xiaohui, Ng Maggie C Y, Smith Albert V, Kuo Jane Z, Taylor Kent D, Freedman Barry I, Bowden Donald W, Penman Alan, Chen Ching J, Craig Jamie E, Adler Sharon G, Chew Emily Y, Cotch Mary Frances, Yaspan Brian, Mitchell Paul, Wang Jie Jin, Klein Barbara E K, Wong Tien Y, Rotter Jerome I, Burdon Kathyrn P, Iyengar Sudha K, Segrè Ayellet V
Abstract excerpt
To identify functionally related genes associated with diabetic retinopathy (DR) risk using gene set enrichment analyses applied to genome-wide association study meta-analyses. METHODS: We analyzed DR GWAS meta-analyses performed on 3246 Europeans and 2611 African Americans with type 2 diabetes. Gene sets relevant to 5 key DR pathophysiology processes were investigated: tissue injury, vascular events, metabolic...
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