Article
Pseudogenes as Competitive Endogenous RNAs: Testing miRNA Dependency.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021
Xu Xiaonan, Karreth Florian A
Abstract excerpt
Pseudogenes may function as competitive endogenous RNAs (ceRNAs), where they regulate the expression of genes by sequestering shared miRNAs. ceRNAs are becoming more extensively identified and studied, and demonstrating the dependence of their effects on miRNA sequestration is critical to establish them as ceRNAs. Here, we outline an experimental approach to assess the miRNA dependency of a candidate pseudogene...
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