Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tethering-facilitated DNA 'opening' and complementary roles of β-hairpin motifs in the Rad4/XPC DNA damage sensor protein.

Nucleic acids research - 2 Dec 2020

Paul Debamita, Mu Hong, Tavakoli Amirrasoul, Dai Qing, Chen Xuejing, Chakraborty Sagnik, He Chuan, Ansari Anjum, Broyde Suse, Min Jung-Hyun

Abstract excerpt

XPC/Rad4 initiates eukaryotic nucleotide excision repair on structurally diverse helix-destabilizing/distorting DNA lesions by selectively 'opening' these sites while rapidly diffusing along undamaged DNA. Previous structural studies showed that Rad4, when tethered to DNA, could also open undamaged DNA, suggesting a 'kinetic gating' mechanism whereby lesion discrimination relied on efficient opening versus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Molecular Dynamics Simulation
Share to Nucleic Acid Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Organophosphorus Compounds

Share to Protein Conformation, alpha-Helical

Share to Protein Conformation, beta-Strand

Share to Protein Interaction Domains and Motifs

Share to Spectrometry, Fluorescence

Share to Thermodynamics

Source

Open in PubMed Open full text

Identifiers

PMID: 33119737
DOI: 10.1093/nar/gkaa909
PMCID: PMC7708039

Genes

XPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tethering-facilitated DNA 'opening' and complementary roles of β-hairpin motifs in the Rad4/XPC DNA damage sensor protein.PMID 33119737Read ↗

A Dynamic Search Mechanism Enables APE1 to Identify AP-Sites in DNASemantic proximity Read ↗

DNA quality control by a lesion sensor pocket of the xeroderma pigmentosum group D helicase subunit of TFIIH.Semantic proximity Read ↗

Turning the Mre11/Rad50 DNA repair complex on its head: lessons from SMC protein hinges, dynamic coiled-coil movements and DNA loop-extrusion?Semantic proximity Read ↗

A Dynamic View of the Interaction of Histone Tails with Clustered Abasic Sites in a Nucleosome Core Particle.Semantic proximity Read ↗

Unusual DNA conformations.Semantic proximity Read ↗

Recognition of helical kinks by xeroderma pigmentosum group A protein triggers DNA excision repair.Semantic proximity Read ↗

Structural Insight into the Mechanism of TFIIH Recognition by the Acidic String of the Nucleotide Excision Repair Factor XPC.Semantic proximity Read ↗

A structural model for the damage-sensing complex in bacterial nucleotide excision repair.Semantic proximity Read ↗

Structural basis of TFIIH activation for nucleotide excision repairSemantic proximity Read ↗

Dissecting the DNA damage response : structural and biochemical insights into the Mec1-Ddc2 checkpoint kinase complexSemantic proximity Read ↗

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.Semantic proximity Read ↗

Structural dynamics of DNA strand break sensing by PARP-1 at a single-molecule levelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.