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Article

Murine models of clonal haematopoiesis to assess mechanisms of cardiovascular disease.

Cardiovascular research - 6 May 2022

Wang Ying, Sano Soichi, Ogawa Hayato, Horitani Keita, Evans Megan A, Yura Yoshimitsu, Miura-Yura Emiri, Doviak Heather, Walsh Kenneth

Abstract excerpt

Clonal haematopoiesis (CH) is a phenomenon whereby somatic mutations confer a fitness advantage to haematopoietic stem and progenitor cells (HSPCs) and thus facilitate their aberrant clonal expansion. These mutations are carried into progeny leucocytes leading to a situation whereby a substantial fraction of an individual's blood cells originate from the HSPC mutant clone. Although this condition rarely...

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Identifiers

PMID: 34164655
DOI: 10.1093/cvr/cvab215
PMCID: PMC9075001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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