Article
HLA-genotyping by next-generation-sequencing reveals shared and unique HLA alleles in two patients with coexisting neuromyelitis optica spectrum disorder and thymectomized myasthenia gravis: Immunological implications for mutual aetiopathogenesis?
Multiple sclerosis and related disorders - 1 Jul 2022
Vakrakou Aigli, Chatzistamatiou Theofanis, Koros Christos, Karathanasis Dimitris, Tentolouris-Piperas Vasileios, Tzanetakos Dimitrios, Stathopoulos Panos, Koutsis Georgios, Spyropoulou-Vlachou Maria, Evangelopoulos Maria-Eleftheria, Stefanis Leonidas, Stavropoulos-Giokas Catherine, Anagnostouli Maria
Abstract excerpt
The exact immunopathogenesis, genetic mechanisms and triggering factors underlying myasthenia gravis (MG) and neuromyelitis optica (NMO) remain unknown and the coexistence may underline an aetiopathogenetic link be- tween these two diseases. We report the cases of two thymectomized patients with acetylcholine receptor (AChR) antibody (Ab)-positive MG who eventually developed AQP4-NMO. Next-Generation Sequencing...
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