Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Electro-steric opening of the CLC-2 chloride channel gate.

Scientific reports - 23 Jun 2021

De Jesús-Pérez José J, Méndez-Maldonado G Arlette, López-Romero Ana E, Esparza-Jasso David, González-Hernández Irma L, De la Rosa Víctor, Gastélum-Garibaldi Roberto, Sánchez-Rodríguez Jorge E, Arreola Jorge

Abstract excerpt

The widely expressed two-pore homodimeric inward rectifier CLC-2 chloride channel regulates transepithelial chloride transport, extracellular chloride homeostasis, and neuronal excitability. Each pore is independently gated at hyperpolarized voltages by a conserved pore glutamate. Presumably, exiting chloride ions push glutamate outwardly while external protonation stabilizes it. To understand the mechanism of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Cattle

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chloride Channels

Share to Chlorides

Share to Ion Channel Gating

Share to Protein Structure, Tertiary

Share to Sequence Alignment

Share to Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 34162897
DOI: 10.1038/s41598-021-92247-3
PMCID: PMC8222222

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Electro-steric opening of the CLC-2 chloride channel gate.PMID 34162897Read ↗

Voltage-dependent and -independent titration of specific residues accounts for complex gating of a ClC chloride channel by extracellular protons.Semantic proximity Read ↗

The voltage-dependent ClC-2 chloride channel has a dual gating mechanism.Semantic proximity Read ↗

Chloride dependence of hyperpolarization-activated chloride channel gates.Semantic proximity Read ↗

Proton sensing of CLC-0 mutant E166D.Semantic proximity Read ↗

Removal of gating in voltage-dependent ClC-2 chloride channel by point mutations affecting the pore and C-terminus CBS-2 domain.Semantic proximity Read ↗

Conformational changes required for H(+)/Cl(-) exchange mediated by a CLC transporter.Semantic proximity Read ↗

Structure of the CLC-1 chloride channel from Homo sapiens.Semantic proximity Read ↗

CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanismSemantic proximity Read ↗

Structure and function of ClC chloride channels.Semantic proximity Read ↗

Helix O modulates voltage dependency of CLC-1.Semantic proximity Read ↗

Mutations in an intracellular vestibule that bifurcates from the pore of ClC-1 chloride ion channels affect anion permeationSemantic proximity Read ↗

Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K2P channel TALK-2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.