Tumor-Naïve Multimodal Profiling of Circulating Tumor DNA in Head and Neck Squamous Cell Carcinoma.

doi:10.1158/1078-0432.CCR-21-0110

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Article

Tumor-Naïve Multimodal Profiling of Circulating Tumor DNA in Head and Neck Squamous Cell Carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2021

Burgener Justin M, Zou Jinfeng, Zhao Zhen, Zheng Yangqiao, Shen Shu Yi, Huang Shao Hui, Keshavarzi Sareh, Xu Wei, Liu Fei-Fei, Liu Geoffrey, Waldron John N, Weinreb Ilan, Spreafico Anna, Siu Lillian L, de Almeida John R, Goldstein David P, Hoffman Michael M, De Carvalho Daniel D, Bratman Scott V

Abstract excerpt

PURPOSE: Circulating tumor DNA (ctDNA) enables personalized treatment strategies in oncology by providing a noninvasive source of clinical biomarkers. In patients with low ctDNA abundance, tumor-naïve methods are needed to facilitate clinical implementation. Here, using locoregionally confined head and neck squamous cell carcinoma (HNSCC) as an example, we demonstrate tumor-naïve detection of ctDNA by...

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Identifiers

PMID: 34158359
DOI: 10.1158/1078-0432.CCR-21-0110
PMCID: PMC9401560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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