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Comprehensive multiparameter genetic analysis improves circulating tumor DNA detection in head and neck cancer patients

23 Jun 2020

Abstract excerpt

INTRODUCTION: Tumor-specific genetic aberrations in cell-free DNA (cfDNA) from plasma are promising biomarkers for diagnosis of recurrent head and neck squamous cell carcinoma (HNSCC). However, the sensitivity when using somatic mutations only in cfDNA is suboptimal. Here, we combined detection of copy number aberrations (CNAs), human papillomavirus (HPV) DNA and somatic mutations in a single sequencing workflow....

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PMID: 32590298
DOI: 10.1016/j.oraloncology.2020.104852

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