Detection of minimal residual disease by next generation sequencing in AL amyloidosis

Abstract excerpt

Although treatment for light chain (AL) amyloidosis targets clonal plasma cells with the goal of achieving a hematologic complete response (CR) and improving organ response, as well as overall survival [ 1 ], some patients do not have organ improvement despite a satisfactory hematologic response. This persistence or worsening of organ dysfunction is potentially related to residual, low-level disease. Improved...

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