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Small Molecule Inhibitors of Activation-Induced Deaminase Decrease Class Switch Recombination in B Cells

7 May 2021

Abstract excerpt

Activation-induced deaminase (AID) not only mutates DNA within the immunoglobulin loci to generate antibody diversity, but it also promotes development of B cell lymphomas. To tame this mutagen, we performed a quantitative high-throughput screen of over 90 000 compounds to see if AID activity could be mitigated. The enzymatic activity was assessed in biochemical assays to detect cytosine deamination and in...

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PMID: 34151211
DOI: 10.1021/acsptsci.1c00064

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