Article
Polymorphisms of Antigen-Presenting Machinery Genes in Non-Small Cell Lung Cancer: Different Impact on Disease Risk and Clinical Parameters in Smokers and Never-Smokers.
Frontiers in immunology - 1 Jan 2021
Wiśniewski Andrzej, Sobczyński Maciej, Pawełczyk Konrad, Porębska Irena, Jasek Monika, Wagner Marta, Niepiekło-Miniewska Wanda, Kowal Aneta, Dubis Joanna, Jędruchniewicz Natalia, Kuśnierczyk Piotr
Abstract excerpt
Lung cancer is strongly associated with cigarette smoking; nevertheless some never-smokers develop cancer. Immune eradication of cancer cells is dependent on polymorphisms of HLA class I molecules and antigen-processing machinery (APM) components. We have already published highly significant associations of single nucleotide polymorphisms (SNPs) of the ERAP1 gene with non-small cell lung cancer (NSCLC) in...
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