Article
Analysis of the binding of hepatitis C virus genotype 1a and 1b E2 glycoproteins to peripheral blood mononuclear cell subsets.
The Journal of general virology - 1 Sept 2005
Yamada Eriko, Montoya Maria, Schuettler Christian G, Hickling Timothy P, Tarr Alexander W, Vitelli Alessandra, Dubuisson Jean, Patel Arvind H, Ball Jonathan K, Borrow Persephone
Abstract excerpt
Hepatitis C virus (HCV) binding to hepatocytes is thought to be mediated via interaction of the E2 glycoprotein with (co-)receptors including CD81 and scavenger receptor class B type I (SR-BI). Here, the expression of CD81 and SR-BI was analysed on peripheral blood mononuclear cell (PBMC) subsets, and the binding of genotype 1 soluble truncated E2 (sE2) proteins to these cells was investigated. All PBMC subsets...
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