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Article

A novel method for evaluating antibody-dependent cell-mediated cytotoxicity by flowcytometry using cryopreserved human peripheral blood mononuclear cells.

Scientific reports - 27 Jan 2016

Yamashita Makiko, Kitano Shigehisa, Aikawa Hiroaki, Kuchiba Aya, Hayashi Mitsuhiro, Yamamoto Noboru, Tamura Kenji, Hamada Akinobu

Abstract excerpt

Analyzing the cytotoxic functions of effector cells, such as NK cells against target cancer cells, is thought to be necessary for predicting the clinical efficacy of antibody-dependent cellular cytotoxicity (ADCC) -dependent antibody therapy. The (51)Cr release assay has long been the most widely used method for quantification of ADCC activity. However, the reproducibilities of these release assays are not...

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Identifiers

PMID: 26813960
DOI: 10.1038/srep19772
PMCID: PMC4728441

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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