Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hepatitis C Virus E2 Envelope Glycoprotein Induces an Immunoregulatory Phenotype in Macrophages.

Hepatology (Baltimore, Md.) - 1 May 2019

Kwon Young-Chan, Meyer Keith, Peng Guangyong, Chatterjee Soumya, Hoft Daniel F, Ray Ranjit

Abstract excerpt

A comprehensive strategy to control hepatitis C virus (HCV) infection needs a vaccine. Our phase I study with recombinant HCV E1/E2 envelope glycoprotein (EnvGPs) as a candidate vaccine did not induce a strong immune response in volunteers. We analyzed the interactions of HCV EnvGPs with human monocyte-derived macrophages as antigen-presenting cells. HCV E2 induced immune regulatory cytokine interleukin (IL)-10...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Differentiation, Myelomonocytic
Share to CD163 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complement C3

Share to Dendritic Cells

Share to Interleukin-10

Share to Proto-Oncogene Proteins c-akt

Share to Tetraspanin 28

Share to Viral Envelope Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 29443378
DOI: 10.1002/hep.29843
PMCID: PMC6092255

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Hepatitis C Virus E2 Envelope Glycoprotein Induces an Immunoregulatory Phenotype in Macrophages.PMID 29443378Read ↗

The macrophage activation marker CD163 is associated with IL28B genotype and hepatic inflammation in chronic hepatitis C virus infected patients.Semantic proximity Read ↗

Signal sequences modulate the immunogenic performance of human hepatitis C virus E2 gene.Semantic proximity Read ↗

Hepatitis C virus E2 envelope protein induces dendritic cell maturation.Semantic proximity Read ↗

Macrophage secretory products induce an inflammatory phenotype in hepatocytes.Semantic proximity Read ↗

Characterisation of antibody dependent cellular phagocytosis in patients infected with Hepatitis C virus with different clinical outcomesSemantic proximity Read ↗

Optimisation and validation of a new method for antibody dependent cellular phagocytosis in hepatitis C virus infection.Semantic proximity Read ↗

Binding of the Hepatitis C Virus E2 Glycoprotein to CD81 Is Strain Specific and Is Modulated by a Complex Interplay between Hypervariable Regions 1 and 2Semantic proximity Read ↗

Analysis of the binding of hepatitis C virus genotype 1a and 1b E2 glycoproteins to peripheral blood mononuclear cell subsets.Semantic proximity Read ↗

Hepatitis C virus structural proteins do not prevent human dendritic cell maturation.Semantic proximity Read ↗

Mutations in the putative HCV-E2 CD81 binding regions and correlation with cell surface CD81 expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.