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Article

Genetic Support of A Causal Relationship Between Iron Status and Type 2 Diabetes: A Mendelian Randomization Study.

The Journal of clinical endocrinology and metabolism - 21 Oct 2021

Wang Xinhui, Fang Xuexian, Zheng Wanru, Zhou Jiahui, Song Zijun, Xu Mingqing, Min Junxia, Wang Fudi

Abstract excerpt

CONTEXT: Iron overload is a known risk factor for type 2 diabetes (T2D); however, iron overload and iron deficiency have both been associated with metabolic disorders in observational studies. OBJECTIVE: Using mendelian randomization (MR), we assessed how genetically predicted systemic iron status affected T2D risk. METHODS: A 2-sample MR analysis was used to obtain a causal estimate. We selected genetic variants...

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Identifiers

PMID: 34147035
DOI: 10.1210/clinem/dgab454
PMCID: PMC8530720

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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