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Genetically predicted biomarkers of iron homeostasis and risk of non-ischemic cardiomyopathy: A mendelian randomization study.

Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 Aug 2024

Huang Hao, Wang Xueying, Yu Yu, Cheng Sijing, Long Tianxin, Niu Hongxia, Hua Wei

Abstract excerpt

BACKGROUND AND AIMS: Both iron overload and iron deficiency have been associated with cardiovascular diseases in observational studies. Previous Mendelian Randomization (MR) studies discovered a protective effect of higher iron status on coronary atrial disease, while a neutral effect on all-cause heart failure. Using two-sample MR, we evaluated how genetically predicted systemic iron status affects the risk of...

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PMID: 38740536
DOI: 10.1016/j.numecd.2024.04.006

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