Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus.

doi:10.1038/s41467-021-24021-y

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Article

Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus.

Nature communications - 18 Jun 2021

Doni Andrea, Parente Raffaella, Laface Ilaria, Magrini Elena, Cunha Cristina, Colombo Federico Simone, Lacerda João F, Campos António, Mapelli Sarah N, Petroni Francesca, Porte Rémi, Schorn Tilo, Inforzato Antonio, Mercier Toine, Lagrou Katrien, Maertens Johan, Lambris John D, Bottazzi Barbara, Garlanda Cecilia, Botto Marina, Carvalho Agostinho, Mantovani Alberto

Abstract excerpt

Serum amyloid P component (SAP, also known as Pentraxin 2; APCS gene) is a component of the humoral arm of innate immunity involved in resistance to bacterial infection and regulation of tissue remodeling. Here we investigate the role of SAP in antifungal resistance. Apcs-/- mice show enhanced susceptibility to A. fumigatus infection. Murine and human SAP bound conidia, activate the complement cascade and enhance...

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PMID: 34145258
DOI: 10.1038/s41467-021-24021-y
PMCID: PMC8213769

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