Sequence Variation of Candida albicans Sap2 Enhances Fungal Pathogenicity via Complement Evasion and Macrophage M2-Like Phenotype Induction.

doi:10.1002/advs.202206713

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Article

Sequence Variation of Candida albicans Sap2 Enhances Fungal Pathogenicity via Complement Evasion and Macrophage M2-Like Phenotype Induction.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Jul 2023

Lin Lan, Wang Moran, Zeng Jingsi, Mao Yehong, Qin Renjie, Deng Jun, Ouyang Xiaohu, Hou Xiaoshuang, Sun Chunyan, Wang Yadan, Cai Yaohua, Li Mingyue, Tian Chunxia, Zhou Xi, Zhang Min, Fan Heng, Mei Heng, Sarapultsev Alexey, Wang Huafang, Zhang Gensheng, Zipfel Peter F, Hu Yu, Hu Desheng, Luo Shanshan

Abstract excerpt

Candida albicans (C. albicans) is an opportunistic pathogen increasingly causing candidiasis worldwide. This study aims to investigate the pattern of systemic immune responses triggered by C. albicans with disease associated variation of Sap2, identifying the novel evasion strategies utilized by clinical isolates. Specifically, a variation in clinical isolates is identified at nucleotide position 817 (G to T)....

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PMID: 37211685
DOI: 10.1002/advs.202206713
PMCID: PMC10369283

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