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Article

Role of Protein A in the Evasion of Host Adaptive Immune Responses by Staphylococcus aureus

28 Aug 2013

Abstract excerpt

UNLABELLED: Heritable defects in human B cell/antibody development are not associated with increased susceptibility to Staphylococcus aureus infection. Protein A (SpA), a surface molecule of S. aureus, binds the Fcγ domain of immunoglobulin (Ig) and cross-links the Fab domain of VH3-type B cell receptors (IgM). Here we generated S. aureus spa variants harboring amino acid substitutions at four key residues in...

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PMID: 23982075
DOI: 10.1128/mbio.00575-13

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