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Article

Susceptibility of mice genetically deficient in SP-A or SP-D gene to invasive pulmonary aspergillosis.

Molecular immunology - 1 Jun 2010

Madan Taruna, Reid Kenneth B M, Clark Howard, Singh Mamta, Nayak Annapurna, Sarma P Usha, Hawgood Samuel, Kishore Uday

Abstract excerpt

Pulmonary surfactant proteins, SP-A and SP-D, are carbohydrate pattern recognition molecules of innate immunity, which significantly enhance phagocytosis and killing of Aspergillus fumigatus, a pathogenic fungus, by neutrophils and macrophages. The present study examined the susceptibility of immunosuppressed SP-A gene deficient (SP-A(-/-)) or SP-D gene deficient (SP-D(-/-)) mice to A. fumigatus conidia challenge...

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Identifiers

PMID: 20413160
DOI: 10.1016/j.molimm.2010.02.027

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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