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Article

E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non-small cell lung cancer.

The Journal of experimental medicine - 2 Aug 2021

Li Ke, Zheng Xufen, Tang Hua, Zang Yuan-Sheng, Zeng Chunling, Liu Xiaoxiao, Shen Yanying, Pang Yuzhi, Wang Simin, Xie Feifei, Lu Xiaojing, Luo Yuxiang, Li Zhang, Bi Wenbo, Jia Xiaona, Huang Tao, Wei Rongqiang, Huang Kenan, Chen Zihao, Zhu Qingchen, He Yi, Zhang Miaoying, Gu Zhizhan, Xiao Yichuan, Zhang Xiaoyang, Fletcher Jonathan A, Wang Yuexiang

Abstract excerpt

Central precocious puberty (CPP), largely caused by germline mutations in the MKRN3 gene, has been epidemiologically linked to cancers. MKRN3 is frequently mutated in non-small cell lung cancers (NSCLCs) with five cohorts. Genomic MKRN3 aberrations are significantly enriched in NSCLC samples harboring oncogenic KRAS mutations. Low MKRN3 expression levels correlate with poor patient survival. Reconstitution of...

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Identifiers

PMID: 34143182
DOI: 10.1084/jem.20210151
PMCID: PMC8217967

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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