Article
The rs6576457 G > A variant in the MKRN3 gene promoter significantly increases the risk of central precocious puberty and lung cancer in Hubei Chinese population.
Human molecular genetics - 8 Nov 2024
Wu Feng, Zhou Weiguang, Yue Zhengchu, Deng Xiangyuan, Kang Wenqiang, Yu Zhiyan, Zhang Haixia, Zhang Bixin, Feng Xianhong, Xiong Qiantao, Chen Bifeng
Abstract excerpt
Makorin RING finger protein 3 (MKRN3) is a key inhibitor of the hypothalamic-pituitary-gonadal (HPG) axis. The association between MKRN3 gene variants and central precocious puberty (CPP) has been repeatedly examined. In a recent study, MKRN3 has been assigned a role of tumor suppressor in lung carcinogenesis. Therefore, it is hypothesized that MKRN3 may be the link between CPP and lung cancer (LC), and certain...
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