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Article

Serum level of NPTX1 is independent of serum MKRN3 in central precocious puberty.

Journal of pediatric endocrinology & metabolism : JPEM - 27 Jan 2021

Jeong Hwal Rim, Yoon Jong Seo, Lee Hye Jin, Shim Yeong Suk, Kang Min Jae, Hwang Il Tae

Abstract excerpt

OBJECTIVES: Makorin ring finger protein 3 (MKRN3) is associated with the initiation of puberty, and loss of function mutation of MKRN3 is the most common genetic cause of central precocious puberty (CPP). A recent study reported that MKRN3 interacts with and suppresses neural pentraxin-1 precursor (NPTX1) activity via polyubiquitination during early puberty in the mouse hypothalamus. This study investigated the...

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Identifiers

PMID: 33180049
DOI: 10.1515/jpem-2020-0402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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