Article
Context-dependent contributions of backbone hydrogen bonding to beta-sheet folding energetics.
Nature - 1 Jul 2004
Deechongkit Songpon, Nguyen Houbi, Powers Evan T, Dawson Philip E, Gruebele Martin, Kelly Jeffery W
Abstract excerpt
Backbone hydrogen bonds (H-bonds) are prominent features of protein structures; however, their role in protein folding remains controversial because they cannot be selectively perturbed by traditional methods of protein mutagenesis. Here we have assessed the contribution of backbone H-bonds to the folding kinetics and thermodynamics of the PIN WW domain, a small beta-sheet protein, by individually replacing its...
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