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Article

The structural and functional role of the three tryptophan residues in Pin1.

Journal of photochemistry and photobiology. B, Biology - 1 May 2015

Wang Jing-Zhang, Xi Lei, Lin Tao, Wang Yu, Zhu Guo-Fei, Du Lin-Fang

Abstract excerpt

Pin1, the only known isomerase catalyzing phosphorylated pSer/pThr-Pro motifs in proteins, plays unique roles in human diseases notably cancers and Alzheimer's disease. Herein, site-directed mutagenesis was employed to construct the tryptophan mutants of Pin1, including W11L, W34L, and W73L. Spectral methodologies, activity measurement, and proteinase resistance analysis were used to investigate the structural...

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PMID: 25837727
DOI: 10.1016/j.jphotobiol.2015.03.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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