Article
Comparison of age at natural menopause in BRCA1/2 mutation carriers with a non-clinic-based sample of women in northern California.
Cancer - 1 May 2013
Lin Wayne T, Beattie Mary, Chen Lee-May, Oktay Kutluk, Crawford Sybil L, Gold Ellen B, Cedars Marcelle, Rosen Mitchell
Abstract excerpt
BACKGROUND: Germline mutations in BRCA1 and BRCA2 (BRCA1/2) are related to an increased lifetime risk of developing breast and ovarian cancer. Although risk-reducing salpingo-oophorectomy reduces the risk of both cancers, loss of fertility is a major concern. A recent study suggested an association between BRCA1 mutation and occult primary ovarian insufficiency. The objective of the current study was to determine...
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