DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis.

doi:10.26508/lsa.202101022

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Article

DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis.

Life science alliance - 1 Jul 2021

Homma Hidenori, Tanaka Hikari, Jin Meihua, Jin Xiaocen, Huang Yong, Yoshioka Yuki, Bertens Christian Jf, Tsumaki Kohei, Kondo Kanoh, Shiwaku Hiroki, Tagawa Kazuhiko, Akatsu Hiroyasu, Atsuta Naoki, Katsuno Masahisa, Furukawa Katsutoshi, Ishiki Aiko, Waragai Masaaki, Ohtomo Gaku, Iwata Atsushi, Yokota Takanori, Inoue Haruhisa, Arai Hiroyuki, Sobue Gen, Sone Masaki, Fujita Kyota, Okazawa Hitoshi

Abstract excerpt

The early-stage pathologies of frontotemporal lobal degeneration (FTLD) remain largely unknown. In VCPT262A-KI mice carrying VCP gene mutation linked to FTLD, insufficient DNA damage repair in neural stem/progenitor cells (NSCs) activated DNA-PK and CDK1 that disabled MCM3 essential for the G1/S cell cycle transition. Abnormal neural exit produced neurons carrying over unrepaired DNA damage and induced...

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Identifiers

PMID: 34130995
DOI: 10.26508/lsa.202101022
PMCID: PMC9715434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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