Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deletion of the lactoperoxidase gene causes multisystem inflammation and tumors in mice.

Scientific reports - 14 Jun 2021

Yamakaze Jayden, Lu Zhe

Abstract excerpt

Strongly oxidative H2O2 is biologically important, but if uncontrolled, would lead to tissue injuries. Lactoperoxidase (LPO) catalyzes the redox reaction of reducing highly reactive H2O2 to H2O while oxidizing thiocyanate (SCN-) to relatively tissue-innocuous hypothiocyanite (OSCN-). SCN- is the only known natural, effective reducing-substrate of LPO; humans normally derive SCN- solely from food. While its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Disease Models, Animal
Share to Hydrogen-Ion Concentration

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hydrogen Peroxide

Share to Inflammation

Share to Mice, Transgenic

Share to Neoplasms

Share to Oxidation-Reduction

Source

Open in PubMed Open full text

Identifiers

PMID: 34127712
DOI: 10.1038/s41598-021-91745-8
PMCID: PMC8203638

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletion of the lactoperoxidase gene causes multisystem inflammation and tumors in mice.PMID 34127712Read ↗

Lactoperoxidase: Properties, Functions and Potential ApplicationsSemantic proximity Read ↗

Nox Enzymes and New Thinking on Reactive Oxygen: A Double-Edged Sword RevisitedSemantic proximity Read ↗

Myeloperoxidase.Semantic proximity Read ↗

Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications.Semantic proximity Read ↗

Tissue-Specific Profiling of Oxidative Stress-Associated Transcriptome in a Healthy Mouse ModelSemantic proximity Read ↗

Myeloperoxidase: Growing importance in cancer pathogenesis and potential drug targetSemantic proximity Read ↗

S-nitrosothiol homeostasis maintained by ADH5 facilitates STING-dependent host defense against pathogensSemantic proximity Read ↗

Evolution of Catalases from Bacteria to HumansSemantic proximity Read ↗

A mouse model to study glutathione limitation <i>in vivo</i>Semantic proximity Read ↗

Metabolic Damage and Premature Thymus Aging Caused by Stromal Catalase DeficiencySemantic proximity Read ↗

Mode of Action of Lactoperoxidase as Related to Its Antimicrobial Activity: A ReviewSemantic proximity Read ↗

Increased Urinary 3-Mercaptolactate Excretion and Enhanced Passive Systemic Anaphylaxis in Mice Lacking Mercaptopyruvate Sulfurtransferase, a Model of Mercaptolactate-Cysteine Disulfiduria.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.