Article
Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications.
Physiological reviews - 1 Jan 2016
Lei Xin Gen, Zhu Jian-Hong, Cheng Wen-Hsing, Bao Yongping, Ho Ye-Shih, Reddi Amit R, Holmgren Arne, Arnér Elias S J
Abstract excerpt
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from aerobic metabolism, as a result of accidental electron leakage as well as regulated enzymatic processes. Because ROS/RNS can induce oxidative injury and act in redox signaling, enzymes metabolizing them will inherently promote either health or disease, depending on the physiological context. It is thus misleading to consider...
Topics
- Animals
- Antioxidants
- Disease Models, Animal
- Enzyme Induction
- Enzyme Repression
- Enzymes
- Gene Knockdown Techniques
- Genetic Predisposition to Disease
- Health Status
- Humans
- Mice, Transgenic
- Nutritional Status
- Oxidation-Reduction