Article
Increased Urinary 3-Mercaptolactate Excretion and Enhanced Passive Systemic Anaphylaxis in Mice Lacking Mercaptopyruvate Sulfurtransferase, a Model of Mercaptolactate-Cysteine Disulfiduria.
International journal of molecular sciences - 27 Jan 2020
Akahoshi Noriyuki, Minakawa Tatsuro, Miyashita Masashi, Sugiyama Uran, Saito Chihiro, Takemoto Rintaro, Honda Akihiro, Kamichatani Waka, Kamata Shotaro, Anan Yasumi, Ishii Isao
Abstract excerpt
Mercaptopyruvate sulfurtransferase (Mpst) and its homolog thiosulfate sulfurtransferase (Tst = rhodanese) detoxify cyanide to thiocyanate. Mpst is attracting attention as one of the four endogenous hydrogen sulfide (H2S)/reactive sulfur species (RSS)-producing enzymes, along with cystathionine β-synthase (Cbs), cystathionine γ-lyase (Cth), and cysteinyl-tRNA synthetase 2 (Cars2). MPST deficiency was found in...
Topics
- Alleles
- Amino Acid Metabolism, Inborn Errors
- Animals
- Biomarkers
- Disease Models, Animal
- Gene Targeting
- Genotype
- Liver
- Mice
- Mice, Knockout
- Mutation
- Sulfhydryl Compounds