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Article

Transmission of Polycystic Ovary Syndrome via Epigenetic Inheritance.

Trends in molecular medicine - 1 Aug 2021

Stener-Victorin Elisabet, Deng Qiaolin

Abstract excerpt

A recent study by Mimouni et al. shows that late gestation exposure to anti-Müllerian hormone (AMH) results in transgenerational transmission of a polycystic ovary syndrome (PCOS)-like phenotype in mice. Altered DNA methylation underlies transmission and was also observed in women with PCOS. Epigenetics-based therapy reversed some PCOS-like phenotypic traits when applied to F3 female mice.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 34127396
DOI: 10.1016/j.molmed.2021.05.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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