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Article

Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood.

Nature medicine - 1 Jun 2018

Tata Brooke, Mimouni Nour El Houda, Barbotin Anne-Laure, Malone Samuel A, Loyens Anne, Pigny Pascal, Dewailly Didier, Catteau-Jonard Sophie, Sundström-Poromaa Inger, Piltonen Terhi T, Dal Bello Federica, Medana Claudio, Prevot Vincent, Clasadonte Jerome, Giacobini Paolo

Abstract excerpt

Polycystic ovary syndrome (PCOS) is the main cause of female infertility worldwide and corresponds with a high degree of comorbidities and economic burden. How PCOS is passed on from one generation to the next is not clear, but it may be a developmental condition. Most women with PCOS exhibit higher levels of circulating luteinizing hormone, suggestive of heightened gonadotropin-releasing hormone (GnRH) release,...

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Source

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Identifiers

PMID: 29760445
DOI: 10.1038/s41591-018-0035-5
PMCID: PMC6098696

Genes

AMH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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