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Article

Novel mutations in DNAH17 cause sperm flagellum defects and their influence on ICSI outcome.

Journal of assisted reproduction and genetics - 1 Oct 2023

Song Bing, Yang Tianjin, Shen Qunshan, Liu Yiyuan, Wang Chao, Li Guanjian, Gao Yang, Cao Yunxia, He Xiaojin

Abstract excerpt

PURPOSE: To identify new mutations in DNAH17 that cause male infertility and analyze intracytoplasmic sperm injection (ICSI) outcomes in patients with DNAH17 mutations. METHODS: A total of five cases of new DNAH17 mutations exhibiting the multiple morphological abnormalities of the sperm flagella (MMAF) phenotype were identified through semen analysis and genetic testing. They were recruited at our reproductive...

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Identifiers

PMID: 37574497
DOI: 10.1007/s10815-023-02897-7
PMCID: PMC10504183

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