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Article

Anaplastic Features in Advanced Prostate Cancer With and Without DNA Damage Repair Mutations.

Clinical genitourinary cancer - 1 Dec 2021

Chau Vincent, Madan Ravi A, Bilusic Marijo, Owens Helen, Cordes Lisa M, Marte Jennifer L, Gulley James L, Lee Jung-Min, Dahut William L, Karzai Fatima

Abstract excerpt

BACKGROUND: Anaplastic prostate cancer has a poor prognosis with limited treatment options. Seven clinical features of anaplastic prostate cancer have been prospectively identified. In this phase II clinical trial, we identified mutations, including DNA damage repair (DDR) mutations, in patients with metastatic castration-resistant prostate cancer (mCRPC) who were treated with durvalumab and olaparib and...

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Identifiers

PMID: 34116956
DOI: 10.1016/j.clgc.2021.05.005
PMCID: PMC9595034

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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