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Article

Taqman-MGB nanoPCR for Highly Specific Detection of Single-Base Mutations.

International journal of nanomedicine - 1 Jan 2021

Xue Zhenrui, You Minli, Peng Ping, Tong Haoyang, He Wanghong, Li Ang, Mao Ping, Xu Ting, Xu Feng, Yao Chunyan

Abstract excerpt

PURPOSE: Detection of single-base mutations is important for real-time monitoring of tumor progression, therapeutic effects, and drug resistance. However, the specific detection of single-base mutations from excessive wild-type background sequences with routine PCR technology remains challenging. Our objective is to develop a simple and highly specific qPCR-based single-base mutation detection method. METHODS:...

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Identifiers

PMID: 34113098
DOI: 10.2147/IJN.S310254
PMCID: PMC8185130

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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