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Article

Reduced genomic cytosine methylation and defective cellular differentiation in embryonic stem cells lacking CpG binding protein.

Molecular and cellular biology - 1 Jun 2005

Carlone Diana L, Lee Jeong-Heon, Young Suzanne R L, Dobrota Erika, Butler Jill Sergesketter, Ruiz Joseph, Skalnik David G

Abstract excerpt

Cytosine methylation at CpG dinucleotides is a critical epigenetic modification of mammalian genomes. CpG binding protein (CGBP) exhibits a unique DNA-binding specificity for unmethylated CpG motifs and is essential for early murine development. Embryonic stem cell lines deficient for CGBP were generated to further examine CGBP function. CGBP(-)(/)(-) cells are viable but show an increased rate of apoptosis and...

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Identifiers

PMID: 15923607
DOI: 10.1128/MCB.25.12.4881-4891.2005
PMCID: PMC1140577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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