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Article

Aberrant DNA Methylation in Human iPSCs Associates with MYC-Binding Motifs in a Clone-Specific Manner Independent of Genetics.

Cell stem cell - 6 Apr 2017

Panopoulos Athanasia D, Smith Erin N, Arias Angelo D, Shepard Peter J, Hishida Yuriko, Modesto Veronica, Diffenderfer Kenneth E, Conner Clay, Biggs William, Sandoval Efren, D'Antonio-Chronowska Agnieszka, Berggren W Travis, Izpisua Belmonte Juan Carlos, Frazer Kelly A

Abstract excerpt

Induced pluripotent stem cells (iPSCs) show variable methylation patterns between lines, some of which reflect aberrant differences relative to embryonic stem cells (ESCs). To examine whether this aberrant methylation results from genetic variation or non-genetic mechanisms, we generated human iPSCs from monozygotic twins to investigate how genetic background, clone, and passage number contribute. We found that...

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Share to Clone Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-myc

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Source

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Identifiers

PMID: 28388429
DOI: 10.1016/j.stem.2017.03.010
PMCID: PMC5444384

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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