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Monocyte and macrophage derived myofibroblasts: Is it fate? A review of the current evidence

9 Jun 2021

Abstract excerpt

Since the discovery of the myofibroblast over 50 years ago, much has been learned about its role in wound healing and fibrosis. Its origin, however, remains controversial, with a number of progenitor cells being proposed. Macrophage-myofibroblast transition (MMT) is a recent term coined in 2014 that describes the mechanism through which macrophages, derived from circulating monocytes originating in the bone...

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PMID: 34107123
DOI: 10.1111/wrr.12946

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