Article
Prediction of the binding mode and resistance profile for a dual-target pyrrolyl diketo acid scaffold against HIV-1 integrase and reverse-transcriptase-associated ribonuclease H.
Physical chemistry chemical physics : PCCP - 26 Sept 2018
Yang Fengyuan, Zheng Guoxun, Fu Tingting, Li Xiaofeng, Tu Gao, Li Ying Hong, Yao Xiaojun, Xue Weiwei, Zhu Feng
Abstract excerpt
The rapid emergence of drug-resistant variants is one of the most common causes of highly active antiretroviral therapeutic (HAART) failure in patients infected with HIV-1. Compared with the existing HAART, the recently developed pyrrolyl diketo acid scaffold targeting both HIV-1 integrase (IN) and reverse transcriptase-associated ribonuclease H (RNase H) is an efficient approach to counteract the failure of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.