Article
Placental mitochondrial DNA mutational load and perinatal outcomes: Findings from a multi-ethnic pregnancy cohort.
Mitochondrion - 1 Jul 2021
Cowell Whitney, Brunst Kelly, Colicino Elena, Zhang Li, Zhang Xiang, Bloomquist Tessa R, Baccarelli Andrea A, Wright Rosalind J
Abstract excerpt
Mitochondria fuel placental activity, with mitochondrial dysfunction implicated in several perinatal complications. We investigated placental mtDNA mutational load using NextGen sequencing in relation to birthweight and gestational length among 358 mother-newborn pairs. We found that higher heteroplasmy, especially in the hypervariable displacement loop region, was associated with shorter gestational length....
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