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Article

Maternal lifetime stress and placental mitochondrial DNA mutational load: Effect modification by maternal characteristics.

Placenta - 1 Aug 2026

Carroll Kecia N, Lesseur Corina, Brunst Kelly J, Colicino Elena, Chiu Yueh-Hsiu Mathilda, Hartman Terryl J, Coull Brent A, Wright Rosalind J

Abstract excerpt

BACKGROUND: Maternal psychosocial stress is associated with perturbations in biological systems, including placental alterations with implications for fetal programming. Here, we examined associations between maternal lifetime stress and placental mitochondrial DNA (mtDNA) mutational load, while considering modifying effects of maternal characteristics. METHODS: In 496 participants from the PRISM cohort, we...

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Identifiers

PMID: 42361646
DOI: 10.1016/j.placenta.2026.06.013
PMCID: PMC13383093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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