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Article

Prenatal particulate matter exposure and mitochondrial mutational load at the maternal-fetal interface: Effect modification by genetic ancestry.

Mitochondrion - 1 Jan 2022

Brunst Kelly J, Hsu Hsiao-Hsien Leon, Zhang Li, Zhang Xiang, Carroll Kecia N, Just Allan, Coull Brent A, Kloog Itai, Wright Robert O, Baccarelli Andrea A, Wright Rosalind J

Abstract excerpt

Prenatal ambient particulate matter (PM2.5) exposure impacts infant development and alters placental mitochondrial DNA abundance. We investigated whether the timing of PM2.5 exposure predicts placental mitochondrial mutational load using NextGen sequencing in 283 multi-ethnic mother-infant dyads. We observed increased PM2.5exposure, particularly during mid- to late-pregnancy and among genes coding for NADH...

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Identifiers

PMID: 34785263
DOI: 10.1016/j.mito.2021.11.003
PMCID: PMC9175302

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