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Article

Association of placental mitochondrial DNA mutations on infant negative affectivity: modifying effects of maternal lifetime stress and infant sex.

Biology of sex differences - 10 Jun 2025

de Pins Agathe M, Hsu Hsiao-Hsien Leon, Wright Rosalind J, Brunst Kelly J

Abstract excerpt

Neuropsychiatric and behavioral disorders impact over 15% of U.S. children, with sex differences in manifestation. Prenatal exposure to psychosocial stress predicts adverse neurodevelopmental outcomes, particularly during gestation. Mechanisms remain poorly understood. Research links prenatal stress exposures with placental mitochondrial DNA (mtDNA) mutational load, suggesting that disrupted mitochondrial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40495250
DOI: 10.1186/s13293-025-00717-4
PMCID: PMC12150558

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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