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Transcriptome sequencing of archived lymphoma specimens is feasible and clinically relevant using exome capture technology

16 Oct 2021

Abstract excerpt

Formalin-fixed, paraffin-embedded (FFPE) specimens are an underutilized resource in medical research, particularly in the setting of transcriptome sequencing, as RNA from these samples is often degraded. We took advantage of an exome capture-based RNA-sequencing protocol to explore global gene expression in paired fresh-frozen (FF) and FFPE samples from 16 diffuse large B-cell lymphoma (DLBCL) patients. While...

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PMID: 34647650
DOI: 10.1002/gcc.23002

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