Article
Association between RAD51, XRCC2 and XRCC3 gene polymorphisms and risk of ovarian cancer: a case control and an in silico study.
Molecular biology reports - 1 May 2021
Gowtham Kumar G, Paul Solomon Franklin Durairaj, Martin Jovita, Manickavasagam M, Sundersingh Shirley, Ganesan Nalini, Ramya R, Usha Rani G, Andrea Mary Francis
Abstract excerpt
Homologous recombination (HR) is one of the important mechanisms in repairing double-strand breaks to maintain genomic integrity and DNA stability from the cytotoxic effects and mutations. Various studies have reported that single nucleotide polymorphisms (SNPs) in the HR-associated genes may have a significant association with ovarian cancer (OCa) risk but the results were inconclusive. In the present study,...
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