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Article

Oncogenic Mutations in PI3K/AKT/mTOR Pathway Effectors Associate with Worse Prognosis in BRAFV600E -Driven Papillary Thyroid Cancer Patients.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2021

Pappa Theodora, Ahmadi Sara, Marqusee Ellen, Johnson Hannah L, Nehs Matthew A, Cho Nancy L, Barletta Justine A, Lorch Jochen H, Doherty Gerard M, Lindeman Neal I, Alexander Erik K, Landa Iñigo

Abstract excerpt

PURPOSE: The extent to which routine genomic sequencing can identify relevant secondary genomic alterations among BRAFV600E -mutant papillary thyroid carcinoma (PTC) is unknown. Such markers would prove highly valuable for prognostic purposes. EXPERIMENTAL DESIGN: We reviewed clinicopathologic data of 225 patients with BRAFV600E -mutant PTC and integrated them with genomic data derived from targeted...

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Share to Phosphatidylinositol 3-Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins B-raf

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Identifiers

PMID: 34088725
DOI: 10.1158/1078-0432.CCR-21-0874

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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