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Generation and characterization of a novel human iPSC line from a resilient Alzheimer's disease patient.

Stem cell research - 1 Oct 2020

Das Debamitra, Li Jiaxin, Liu Senquan, Oh Esther, Cheng Linzhao, Lyketsos Constantine, Mahairaki Vasiliki

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disease that is the major cause of dementia in older people. Here, we report the derivation of human induced pluripotent stem cells (iPSCs) from an AD patient at age of 80 who has the APOE ε4/ε4 genotype and is resilient to cognitive decline for 10 years. The iPSCs reprogrammed from the blood cells of this patient by transient expression of pluripotency...

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Identifiers

PMID: 32916633
DOI: 10.1016/j.scr.2020.101979

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